Transforming growth factor-beta receptor-II up-regulation during wound healing in previously irradiated graft beds in vivo.


Wound healing disorders may often present in patients with head and neck cancer after surgical interventions, particularly in preirradiated tissue. Inflammatory changes and the expression of cytokines can lead to induction of fibrosis. The isoforms of the transforming growth factor beta (TGFbeta1-3) play a key role for this process. It has been shown that… (More)


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