Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys.

@article{Yoshioka1993TransformingGF,
  title={Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys.},
  author={Koichiro Yoshioka and Tsukasa Takemura and Kazuo Murakami and Mituru Okada and Satoshi Hino and Hiroyuki Miyamoto and Sunao Maki},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1993},
  volume={68 2},
  pages={154-63}
}
BACKGROUND Evidence indicates a key role for transforming growth factor-beta (TGF-beta) in the accumulation of pathologic extracellular matrix in experimental glomerular injury. The aim of this study was to elucidate the expression of TGF-beta and its role in human glomerulonephritis. EXPERIMENTAL DESIGN Expression of TGF-beta 1 in normal and diseased human kidneys was examined by immunohistochemical staining with two antibodies (Ab1 and Ab2), and by in situ hybridization with an… CONTINUE READING