Transforming growth factor beta peptide antagonists and their conversion to partial agonists.

@article{Huang1997TransformingGF,
  title={Transforming growth factor beta peptide antagonists and their conversion to partial agonists.},
  author={Shuan Shian Huang and Qingdu Liu and F. E. Johnson and Y Konish and Jung San Huang},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 43},
  pages={27155-9}
}
Transforming growth factor beta (TGF-beta) has been implicated in the pathogenesis of various human diseases. Synthetic TGF-beta antagonists therefore could have therapeutic utility. Here we show the development of such compounds. Three synthetic pentacosapeptides designated beta125-(41-65), beta225-(41-65), and beta325-(41-65), whose amino acid sequences correspond to the 41st to 65th amino acid residues of TGF-beta1, TGF-beta2, and TGF-beta3, respectively, inhibit the binding of 125I-labeled… CONTINUE READING