Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

@article{Edwards1987TransformingGF,
  title={Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.},
  author={Dylan R W Edwards and Gillian Murphy and J. Joshua Reynolds and S E Whitham and Andy J P Docherty and Peter Angel and John K. Heath},
  journal={The EMBO journal},
  year={1987},
  volume={6 7},
  pages={1899-904}
}
Exposure of quiescent MRC-5 human fibroblasts to growth factors such as epidermal growth factor, basic fibroblast growth factor or embryonal carcinoma-derived growth factor resulted in the induction of mRNA transcripts encoding the metalloproteinases collagenase and stromelysin and the specific metalloproteinase inhibitor TIMP, whilst expression of collagen and fibronectin was relatively unaffected. Exposure of quiescent cells to growth factors in the presence of transforming growth factor beta… CONTINUE READING
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