Transforming growth factor-beta is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells.

@article{Baricos1999TransformingGF,
  title={Transforming growth factor-beta is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells.},
  author={William H. Baricos and Shirley L Cortez and M Deboisblanc and Shi Xin},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1999},
  volume={10 4},
  pages={790-5}
}
Accumulation of the glomerular extracellular matrix (ECM) is a pivotal event in the progression from acute glomerular injury to end-stage renal disease. Although enhanced ECM synthesis has been demonstrated to contribute to ECM accumulation, the role of decreased ECM degradation is largely unknown. It was previously shown that glomerular ECM degradation is mediated by a plasminogen activator (PA)/plasmin/matrix metalloproteinase 2 (MMP-2) cascade. However, little information is available… CONTINUE READING

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