Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

@article{Centrella1987TransformingGF,
  title={Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.},
  author={Michael Centrella and Thomas L. McCarthy and Ernesto Canalis},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 6},
  pages={2869-74}
}
Transforming growth factor beta (TGF beta) stimulates cell replication in fetal rat calvariae, and studies with isolated bone cells suggest that the primary mitogenically responsive cell is of the osteoblast lineage. The effect of TGF beta on bone cell replication is biphasic and depends on both the TGF beta concentration and cell density in monolayer culture. After 23 h of treatment, DNA synthesis in confluent cells is progressively enhanced by 0.15-15 ng/ml TGF beta; but in subconfluent cells… CONTINUE READING
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Biochemistry 2 3 ,

  • J. MassaguC
  • 1984

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