Transforming growth factor-beta initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform.

@article{George2000TransformingGF,
  title={Transforming growth factor-beta initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform.},
  author={Jeanne W. George and Sophie S. W. Wang and A M Sevcsik and Michele Sanicola and Richard L. Cate and Victor E. Koteliansky and Daniel M. Bissell},
  journal={The American journal of pathology},
  year={2000},
  volume={156 1},
  pages={115-24}
}
A prominent feature of the hepatic response to injury is production of a fetal isoform of fibronectin, a splice variant containing the EIIIA region, which appears very early after injury and derives from sinusoidal endothelial cells. Previous studies have shown that it is instrumental in initiating the cellular response to injury, specifically the conversion of resting stellate cells to myofibroblast-like cells. The present work describes the regulation of this change in fibronectin expression… CONTINUE READING
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