Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis

@inproceedings{Zhu2012TransformingGF,
  title={Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis},
  author={Yaohui Zhu and Tugba Colak and Mohan M. Shenoy and Liansheng Liu and Kshama Mehta and Reetesh K Pai and Bende Zou and Xinmin Simon Xie and Pankaj Jay Pasricha},
  booktitle={Molecular pain},
  year={2012}
}
BACKGROUND Transforming growth factor beta (TGFβ) is upregulated in chronic inflammation, where it plays a key role in wound healing and promoting fibrosis. However, little is known about the peripheral effects of TGFβ on nociception. METHODS We tested the in vitro effects of TGFβ1 on the excitability of dorsal root ganglia (DRG) neurons and the function of potassium (K) channels. We also studied the effects of TGFβ1 infusion on pain responses to noxious electrical stimulation in healthy rats… CONTINUE READING
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