Transforming growth factor-beta induces airway smooth muscle hypertrophy.

  title={Transforming growth factor-beta induces airway smooth muscle hypertrophy.},
  author={Adam M Goldsmith and J Kelley Bentley and Limei Zhou and Yue Xia Jia and Khalil N. Bitar and Diane C Fingar and Marc B Hershenson},
  journal={American journal of respiratory cell and molecular biology},
  volume={34 2},
Although smooth muscle hypertrophy is present in asthmatic airways, little is known about the biochemical pathways regulating airway smooth muscle protein synthesis, cell size, or accumulation of contractile apparatus proteins. We sought to develop a model of airway smooth muscle hypertrophy in primary cells using a physiologically relevant stimulus. We hypothesized that transforming growth factor (TGF)-beta induces hypertrophy in primary bronchial smooth muscle cells. Primary human bronchial… CONTINUE READING


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