Transforming growth factor-beta-induced upregulation of transforming growth factor-beta receptor expression in pancreatic regeneration.

@article{Menke1999TransformingGF,
  title={Transforming growth factor-beta-induced upregulation of transforming growth factor-beta receptor expression in pancreatic regeneration.},
  author={Andr{\'e} Menke and Irmlind Geerling and Klaudia Giehl and Roger Vogelmann and Max Reinshagen and Guido Adler},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1449 2},
  pages={178-85}
}
The transforming growth factor-beta (TGFbeta) signaling pathway is one important player in the regulation of extracellular matrix turnover and cell proliferation in epithelial regeneration. We used cerulein-induced pancreatitis in rats as a model to investigate the regulation of TGFbeta receptor type I and type II expression on protein and messenger RNA level during regeneration. In the regenerating pancreas, mRNA levels of TGFbeta receptor I and II were significantly increased with a maximum… CONTINUE READING

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