Transforming growth factor-beta in cutaneous melanoma.

  title={Transforming growth factor-beta in cutaneous melanoma.},
  author={Delphine Javelaud and Vasileia-Ismini Alexaki and Alain Mauviel},
  journal={Pigment cell & melanoma research},
  volume={21 2},
Transforming growth factor-beta (TGF-beta) plays a complex role during carcinogenesis. It may either act as a tumor suppressor through its broad antiproliferative potential or as a tumor promoter either via direct effects on tumor cell aggressiveness or indirectly by modulating stromal responses, angiogenesis and immune surveillance. Increased production of TGF-beta by cancer cells is often associated with tumor grade. Melanoma cells largely escape cell cycle arrest normally induced by TGF-beta… CONTINUE READING