Transforming growth factor-beta expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension.

@article{Tahira2002TransformingGF,
  title={Transforming growth factor-beta expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension.},
  author={Yoshiko Tahira and Noboru Fukuda and Morito Endo and Ryo Suzuki and Yukihiro Ikeda and Hiroto Takagi and Koichi Matsumoto and Katsuo Kanmatsuse},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2002},
  volume={25 6},
  pages={911-8}
}
Transforming growth factor (TGF)-beta activity is involved in several cardiovascular diseases owing to its effects on the growth of vascular smooth muscle cells and induction of extracellular matrix formation. We evaluated expression of TGF-beta in cardiovascular organs from stroke-prone spontaneously hypertensive rats (SHR-SP) which show severe cardiovascular damages with the development of hypertension. Twelve-week-old Wistar-Kyoto (WKY)/Izm rats and SHR-SP/Izm were loaded with 1% salt for 4… CONTINUE READING

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