Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo.

  title={Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo.},
  author={David John Grainger and James C. Metcalfe and Andrew A. Grace and Dan Mosedale},
  journal={Journal of cell science},
  volume={111 ( Pt 19)},
Variations in the levels of smooth muscle-specific isoforms of contractile proteins have been reported to occur in many different vascular diseases. However, although much work has been done in vitro to investigate the regulation of smooth muscle cell differentiation, the molecular mechanisms which regulate the differentiation of vascular smooth muscle tissue in vivo are unknown. Using quantitative immunofluorescence, we show that in rat arteries levels of smooth muscle differentiation markers… CONTINUE READING


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