Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells.

@article{Ohgushi2005TransformingGF,
  title={Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells.},
  author={Masatoshi Ohgushi and Shunsuke Kuroki and Hiroshi Fukamachi and Lorraine Ann O'reilly and Keisuke Kuida and Andreas Strasser and Shin Yonehara},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 22},
  pages={
          10017-28
        }
}
Transforming growth factor beta (TGF-beta) has been implicated in the maintenance of homeostasis in various organs, including the gastric epithelium. In particular, TGF-beta-induced signaling was shown to be required for the differentiation-associated physiological apoptosis of gastric epithelial cells, but its mechanism has not been well understood. In this study, the molecular mechanism of TGF-beta-induced apoptosis was analyzed in a human gastric epithelial cell line, SNU16, as an in vitro… CONTINUE READING

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