Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression.

@article{Karsdal2003TransformingGF,
  title={Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression.},
  author={Morten Asser Karsdal and Pernille Hjorth and Kim S. Henriksen and Tove Kirkegaard and Karina Lishmann Nielsen and Henriette Lou and Jean-Marie Delaiss{\'e} and Niels T{\ae}kker Foged},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 45},
  pages={44975-87}
}
Although RANK-L is essential for osteoclast formation, factors such as transforming growth factor-beta (TGF-beta) are potent modulators of osteoclastogenic stimuli. To systematically investigate the role of TGF-beta in human osteoclastogenesis, monocytes were isolated from peripheral blood by three distinct approaches, resulting in either a lymphocyte-rich, a lymphocyte-poor, or a pure osteoclast precursor (CD14-positive) cell population. In each of these osteoclast precursor populations, the… CONTINUE READING

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