Transforming growth factor beta and progression of renal disease.

  title={Transforming growth factor beta and progression of renal disease.},
  author={P. McCullough August and Manikkam Suthanthiran},
  journal={Kidney international. Supplement},
End-stage renal disease (ESRD) is more frequent in African Americans compared to whites. Many factors may be responsible, including genetic differences, increased prevalence of risk factors, and socioeconomic factors; however, to date, these proposed genetic or environmental factors have not provided a satisfactory explanation for the increased risk of ESRD in African Americans. Because renal fibrosis is a correlate of progressive renal failure and a dominant feature of ESRD, and because… CONTINUE READING