Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells.

@article{Kurpinski2010TransformingGF,
  title={Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells.},
  author={Kyle T Kurpinski and H. January Lam and Julia Chu and Aijun Wang and Ahra Kim and Eric Tsay and Smita Agrawal and David V. Schaffer and Song Li},
  journal={Stem cells},
  year={2010},
  volume={28 4},
  pages={734-42}
}
The differentiation of stem cells into smooth muscle cells (SMCs) plays an important role in vascular development and remodeling. In addition, stem cells represent a potential source of SMCs for regenerative medicine applications such as constructing vascular grafts. Previous studies have suggested that various biochemical factors, including transforming growth factor-beta (TGF-beta) and the Notch pathway, may play important roles in vascular differentiation. However, the interactions of these… CONTINUE READING