Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury.

@article{Yoshida2005TransformingGF,
  title={Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury.},
  author={Katsunori Yoshida and Koichi Matsuzaki and Shigeo Mori and Yoshiya Tahashi and Hideo Yamagata and Fukiko Furukawa and Toshihito Seki and Mikio Nishizawa and Junichi Fujisawa and Kazuichi Okazaki},
  journal={The American journal of pathology},
  year={2005},
  volume={166 4},
  pages={1029-39}
}
After liver injury, transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF) regulate the activation of hepatic stellate cells (HSCs) and tissue remodeling. Mechanisms of PDGF signaling in the TGF-beta-triggered cascade are not completely understood. TGF-beta signaling involves phosphorylation of Smad2 and Smad3 at linker and C-terminal regions. Using antibodies to distinguish Smad2/3 phosphorylated at linker regions from those phosphorylated at C-terminal regions… CONTINUE READING
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