Transforming growth factor-beta and fibrosis.

  title={Transforming growth factor-beta and fibrosis.},
  author={Franck Verrecchia and Alain Mauviel},
  journal={World journal of gastroenterology},
  volume={13 22},
Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Elevated TGF-beta expression in affected organs, and subsequent deregulation of TGF-beta functions, correlates with the abnormal… CONTINUE READING
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