Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

@article{Pietenpol1990TransformingGF,
  title={Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.},
  author={Jennifer A. Pietenpol and Jeffrey T. Holt and Roland Stein and Harold L. Moses},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 10},
  pages={3758-62}
}
Transforming growth factor beta 1 (TGF-beta 1) is a potent growth inhibitor for many cell types, including most epithelial cells. However, the mechanism of growth inhibition is unknown. In skin keratinocytes, TGF-beta 1 has been shown to inhibit growth and to rapidly reduce c-myc expression. It has been demonstrated that protein synthesis is required for TGF-beta 1 regulation of c-myc in keratinocytes. Here we present evidence that treatment of mouse BALB/MK keratinocyte cells with either… CONTINUE READING

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