Transforming growth factor-beta 1 stimulates or inhibits cell growth via down- or up-regulation of p21/Waf1.

Abstract

Transforming growth factor-beta (TGF-beta) regulates cell proliferation positively or negatively. The mitoinhibition by TGF-beta has been attributed to induction of cyclin-dependent kinase (CDK) inhibitors, such as p15/ Ink4B, p27/Kip1, and p21/Waf1 also known as Cip1 and Sdi1. However, the biological process by which TGF-beta exerts the stimulatory effects… (More)

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@article{Miyazaki1998TransformingGF, title={Transforming growth factor-beta 1 stimulates or inhibits cell growth via down- or up-regulation of p21/Waf1.}, author={M. Miyazaki and Rikiya Ohashi and T. Tsuji and Kazunori Mihara and Eiichi Gohda and M. Namba}, journal={Biochemical and biophysical research communications}, year={1998}, volume={246 3}, pages={873-80} }