Transforming growth factor-beta 1 stimulates bone ongrowth to weight-loaded tricalcium phosphate coated implants: an experimental study in dogs.

@article{Lind1996TransformingGF,
  title={Transforming growth factor-beta 1 stimulates bone ongrowth to weight-loaded tricalcium phosphate coated implants: an experimental study in dogs.},
  author={Martin Lind and S\oren Overgaard and B Ongpipattanakul and Tue Nguyen and Cody B{\"u}nger and Kjeld S\oballe},
  journal={The Journal of bone and joint surgery. British volume},
  year={1996},
  volume={78 3},
  pages={377-82}
}
Bone growth into cementless prosthetic components is compromised by osteoporosis, by any gap between the implant and the bone, by micromotion, and after the revision of failed prostheses. Recombinant human transforming growth factor-beta 1 (rhTGF-beta 1) has recently been shown to be a potent stimulator of bone healing and bone formation in various models in vivo. We have investigated the potential of rhTGF-beta 1, adsorbed on to weight-loaded tricalcium phosphate (TCP) coated implants, to… CONTINUE READING

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