Transforming growth factor beta 1-like immunoreactivity in the pituitary gland of the rat: effect of estrogen.

@article{Burns1993TransformingGF,
  title={Transforming growth factor beta 1-like immunoreactivity in the pituitary gland of the rat: effect of estrogen.},
  author={G. Burns and D. Sarkar},
  journal={Endocrinology},
  year={1993},
  volume={133 3},
  pages={
          1444-9
        }
}
We have recently shown that transforming growth factor-beta 1 (TGF beta 1) is produced in the rat pituitary gland and inhibits the secretion of PRL and the estrogen-induced growth of lactotropes. In this study, we sought to ascertain whether TGF beta 1 inhibits lactotropic functions by an autocrine or paracrine mechanism. Our techniques consisted of localizing the pituitary distribution of the growth factor immunoreactivity and measuring changes in pituitary TGF beta 1 and PRL levels in the… Expand
Transforming Growth Factor-β Regulation of Estradiol-Induced Prolactinomas
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