Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro.

@article{Snapper1993TransformingGF,
  title={Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro.},
  author={Clifford M Snapper and Wendy O Waegell and Hans T.H. Beernink and James R. Dasch},
  journal={Journal of immunology},
  year={1993},
  volume={151 9},
  pages={4625-36}
}
Addition of transforming growth factor-beta 1 (TGF-beta 1) to in vitro cultures of murine B cells activated with bacterial LPS selectively stimulates IgG2b and IgA class switching and decreases cellular proliferation. To assess a possible role for endogenous TGF-beta in modulating the Ig isotypes produced by LPS-activated cells, we utilized a neutralizing… CONTINUE READING