Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.

Abstract

Transforming growth factor-beta (TGF-beta) is a major modulator of the extracellular matrix and cell growth, and shows affinity for and interaction with several substances present in plaques in Alzheimer's disease (AD). In order to examine a possible role of TGF-beta in plaque biogenesis, we studied its distribution in the limbic system of AD and Down's… (More)

Topics

Cite this paper

@article{Wal1993TransformingGF, title={Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.}, author={Edwin van der Wal and Fernando G{\'o}mez-Pinilla and Carl Cotman}, journal={Neuroreport}, year={1993}, volume={4 1}, pages={69-72} }