Transforming growth factor-beta 1 inhibits ovarian androgen production: gene expression, cellular localization, mechanisms(s), and site(s) of action.

@article{Hernndez1990TransformingGF,
  title={Transforming growth factor-beta 1 inhibits ovarian androgen production: gene expression, cellular localization, mechanisms(s), and site(s) of action.},
  author={Emma R. Hern{\'a}ndez and A. Hurwitz and Donna W Payne and Arun M. Dharmarajan and Anthony F. Purchio and Eli Y Adashi},
  journal={Endocrinology},
  year={1990},
  volume={127 6},
  pages={2804-11}
}
It is the aim of this study to establish ovarian transforming growth factor-beta 1 (TGF beta 1) gene expression, to reevaluate its cellular localization, and to explore potential interactions of this regulatory peptide on ovarian androgen biosynthesis. Northern analysis of whole ovarian polyadenylated RNA revealed a single 2.5-kilobase transcript corresponding to the TGF beta 1 precursor. Immunohistochemical staining localized the protein to the thecal-interstitial (interfollicular) compartment… CONTINUE READING

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