Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

@article{Desmoulire1993TransformingGF,
  title={Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts},
  author={Alexis Desmouli{\`e}re and Antoine Geinoz and Franqoise Gabbiani and Giulio Gabbiani},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={122},
  pages={103 - 111}
}
Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of alpha-SM actin, the actin isoform typical of vascular SM cells. Myofibroblasts have been proposed to play a role in wound contraction and in retractile phenomena observed during fibrotic diseases. We show here that the subcutaneous administration of transforming growth factor-beta 1 (TGF beta 1… CONTINUE READING
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