Transforming growth factor-beta 1 induces alpha-smooth muscle-actin expression in cultured human and monkey trabecular meshwork.

@article{Tamm1996TransformingGF,
  title={Transforming growth factor-beta 1 induces alpha-smooth muscle-actin expression in cultured human and monkey trabecular meshwork.},
  author={Ernst R Tamm and Axel Siegner and Astrid Baur and Elke L{\"u}tjen-Drecoll},
  journal={Experimental eye research},
  year={1996},
  volume={62 4},
  pages={389-97}
}
Transforming growth factor-beta 1 (TGF-beta 1) induces alpha-smooth muscle (sm)-actin expression and a contractile myofibroblast-like phenotype in a considerable number of different cell types. Since alpha-sm-actin is expressed in some of the resident human trabecular meshwork (TM) cells in situ, and TGF-beta 1 is synthesized by TM in vitro, alpha-sm-actin expression in TM might also be under the influence of TGF-beta 1. To assess this question, TM cultures were initiated from the eyes of three… CONTINUE READING

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