Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

@article{Elbendary1994TransformingGF,
  title={Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.},
  author={A A Elbendary and Andrew Berchuck and Patricia L Davis and Laura Jean Havrilesky and Robert C. Bast and James Dirk Iglehart and Jeffrey R. Marks},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1994},
  volume={5 12},
  pages={1301-7}
}
Transforming growth factor beta (TGF beta) is an important regulator of cellular proliferation. In normal ovarian epithelial cells, TGF beta acts to inhibit growth. However, in ovarian cancer cell lines, this effect is usually lost. Although the regulatory pathway of TGF beta remains unclear, TGF beta-treated cells arrest late in G1. This inhibition appears to involve blocking of the cyclin-dependent kinase phosphorylation of the retinoblastoma protein. Recently, a general inhibitor of cyclin… CONTINUE READING

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