Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.

@article{Nakatsukasa1990TransformingGF,
  title={Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.},
  author={Harushige Nakatsukasa and R. Poukka Evarts and Chu Chieh Hsia and Snorri Thorgeirsson},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1990},
  volume={63 2},
  pages={171-80}
}
The temporal and cellular distribution of transforming growth factor (TGF)-beta 1 and procollagen alpha 1(I) transcripts were examined during regeneration and early fibrosis of rat liver using in situ hybridization and Northern blot analyses. Surgical two-thirds partial hepatectomy (mechanical partial hepatectomy (PH)) and carbon tetrachloride administration (chemical PH) were used to initiate liver regeneration and fibrosis, respectively. Enhancement of TGF-beta 1 gene expression appeared as… CONTINUE READING
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