Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis.

@article{Yuen2002TransformingGF,
  title={Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis.},
  author={Man Fung Yuen and Suzanne Norris and Lee W. Evans and Peter G. Langley and Robin D. Hughes},
  journal={Scandinavian journal of gastroenterology},
  year={2002},
  volume={37 2},
  pages={
          233-8
        }
}
BACKGROUND Transforming growth factor-beta 1 (TGF-beta1) exerts an inhibitory effect on DNA synthesis in hepatocytes. Activin, through different mechanisms, also exhibits an apoptotic effect on hepatocytes. Follistatin antagonizes the actions of activin. METHODS Patients with hepatocellular carcinoma (HCC, n = 20), patients with alcoholic cirrhosis (n = 12), patients with cirrhosis due to other causes (n = 5) and normal controls (n = 19) were studied. TGF-beta1, activin and follistatin… CONTINUE READING

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