Transforming growth factor beta (TGF beta)-induced nuclear localization of apolipoprotein J/clusterin in epithelial cells.

@article{Reddy1996TransformingGF,
  title={Transforming growth factor beta (TGF beta)-induced nuclear localization of apolipoprotein J/clusterin in epithelial cells.},
  author={K B Yadavendra Reddy and Guo-zhang Jin and Mary C. Karode and Judith A. K. Harmony and Philip H Howe},
  journal={Biochemistry},
  year={1996},
  volume={35 19},
  pages={
          6157-63
        }
}
Apolipoprotein J (apoJ)/clusterin was first identified as an 80 kDa secretory glycoprotein present in most body fluids. It has been implicated in a variety of physiological processes including cellular differentiation and apoptosis. We demonstrate here that in addition to the well characterized secreted form of the protein, there exists an intracellular, nuclear form of apoJ. This intracellular form of the protein is induced to accumulate in the nucleus of two epithelial cell lines (HepG2 and… CONTINUE READING

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