Transforming growth factor beta (TGF-beta) and autoimmunity.

  title={Transforming growth factor beta (TGF-beta) and autoimmunity.},
  author={Christopher Aoki and Andrea T. Borchers and Ming Li and Richard A Flavell and Christopher L Bowlus and Aftab A Ansari and M Eric Gershwin},
  journal={Autoimmunity reviews},
  volume={4 7},
TGF-beta1 deficient mice develop multifocal inflammatory autoimmune disease and serve as a valuable animal model of autoimmunity. Transgenic expression of a dominant negative form of TGF-beta receptor type II in T cells have enabled the study of cell lineage specific effects of TGF-beta providing clues to the potential etiology of autoimmunity. These studies suggest that TGF-beta deficiency may induce autoimmune disease by influencing a number of immunological phenomena including lymphocyte… CONTINUE READING
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