Transforming growth factor beta: the good, the bad, and the ugly

@article{Wahl1994TransformingGF,
  title={Transforming growth factor beta: the good, the bad, and the ugly},
  author={Sharon M. Wahl},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={1587 - 1590}
}
A is often the case with peptide growth factors and cytokines, the original activity discovered and identified as TGF-3 merely represented the tip of the iceberg. Not only does it regulate growth, as evident by its name, but TGF-B mediates far-ranging biologic processes including inflammation and host defense, in addition to development, tissue repair, and tumorigenesis. Released locally from platelet stores early in an inflammatory response, TGF-3 is then generated by inflammatory cells… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

TGF-/3 in inflammation. A cause and a cure

S. M. Wahl
  • J. Clin. Irnmunol
  • 1992
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Immune dysregulation in TGF-81 deficient mice

M. Christ, A. Kulkarni, +5 authors S. M. Wahl
  • J. Immunol
  • 1994
VIEW 1 EXCERPT

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
VIEW 1 EXCERPT