Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy.

@article{McGowan2004TransformingGF,
  title={Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy.},
  author={Tracy A McGowan and Yanqing Zhu and Kumar Sharma},
  journal={Current diabetes reports},
  year={2004},
  volume={4 6},
  pages={447-54}
}
Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming growth factor-beta (TGF-beta) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies have not only demonstrated the beneficial effects of blocking TGF-beta on matrix accumulation but have also found that blocking TGF-beta may have important hemodynamic effects that… CONTINUE READING
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