Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.

@article{Romano1992TransformingGF,
  title={Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.},
  author={M{\'a}rio Romano and W. H. Polk and Joseph A. Awad and Carlos L. Arteaga and Lillian B. Nanney and Michael J. Wargovich and Eugene R. Kraus and Clement Richard Boland and Robert J Coffey},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 6},
  pages={2409-21}
}
This study was designed to determine whether transforming growth factor alpha (TGF alpha) protects rat gastric mucosa against ethanol- and aspirin-induced injury. Systemic administration of TGF alpha dose-dependently decreased 100% ethanol-induced gastric mucosal injury; a dose of 50 micrograms/kg delivered intraperitoneally 15 min before ethanol decreased macroscopic mucosal injury by > 90%. At the microscopic level, TGF alpha prevented deep gastric necrotic lesions and reduced disruption of… CONTINUE READING

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