Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells.

@article{Smith1995TransformingGF,
  title={Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells.},
  author={Gilbert H Smith and R. Douglas Sharp and Edith Claudia Kordon and Chamelli Jhappan and Glenn Merlino},
  journal={The American journal of pathology},
  year={1995},
  volume={147 4},
  pages={1081-96}
}
Transforming growth factor (TGF)-alpha stimulates the growth and development of mammary epithelial cells and is implicated in the pathogenesis of human breast cancer. In this report we evaluate the consequences of overexpressing TGF-alpha in the mammary gland of transgenic mice and examine associated cellular mechanisms. When operating on a FVB/N genetic background (line MT100), TGF-alpha induced the stochastic development of mammary adenomas and adenocarcinomas f secretory epithelial origin in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…