Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.

@article{Knebelmann1998TransformingGF,
  title={Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.},
  author={Bertrand Knebelmann and Subbian Ananth and Herbert Cohen and Vikas P Sukhatme},
  journal={Cancer research},
  year={1998},
  volume={58 2},
  pages={226-31}
}
The von Hippel-Lindau (VHL) tumor suppressor gene has a critical role in the pathogenesis of clear cell renal cell carcinoma (RCC), because VHL mutations have been found in both VHL disease-associated and sporadic RCC. Overexpression of transforming growth factor (TGF)-alpha has been observed in numerous RCC tumors and cell lines, and TGF-alpha has been demonstrated to support RCC cell growth through an autocrine loop. We demonstrate here that VHL substantially decreases TGF-alpha message and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis

Stem Cell Reviews and Reports • 2015
View 17 Excerpts
Highly Influenced

The VHL/HIF axis in clear cell renal carcinoma.

Seminars in cancer biology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…