Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model.

@article{GuerraCrespo2009TransformingGF,
  title={Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model.},
  author={Magdalena Guerra-Crespo and Darius Gleason and Andres Sistos and T Toosky and Ihsan Solaroğlu and John H Zhang and Peter J. Bryant and James H. Fallon},
  journal={Neuroscience},
  year={2009},
  volume={160 2},
  pages={470-83}
}
Transforming growth factor-alpha (TGFalpha) is a powerful endogenous mitogen and neurotrophic factor, which has previously been shown to induce a massive proliferative response in the brains of Parkinson's disease model rats injured by an acute neurotoxic lesion. We now show that TGFalpha can also produce a massive proliferative response in rat brains subjected to stroke caused by a middle cerebral artery occlusion (MCAO), even when the growth factor is administered as late as 4 weeks after… CONTINUE READING

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