Transforming growth factor alpha induces angiogenesis and neurogenesis following stroke.

@article{Leker2009TransformingGF,
  title={Transforming growth factor alpha induces angiogenesis and neurogenesis following stroke.},
  author={Ronen Robert Leker and Zsuzsanna Eszter T{\'o}th and Tal Shahar and Riccardo Cassiani-Ingoni and Ildik{\'o} Szalayova and Sharon Key and Andr{\'a}s Bratincs{\'a}k and {\'E}va Mezey},
  journal={Neuroscience},
  year={2009},
  volume={163 1},
  pages={233-43}
}
The cytokine transforming growth factor alpha (TGF alpha) has proangiogenic and proneurogenic effects and can potentially reduce infarct volumes. Therefore, we administered TGF alpha or vehicle directly into the area surrounding the infarct in female mice that received gender-mismatched bone marrow transplants from green fluorescent protein (GFP)-expressing males prior to undergoing permanent middle cerebral artery occlusion. Newborn cells were tracked with bromodeoxyuridine (BrdU) labeling and… CONTINUE READING