Transforming growth factor alpha acts as a gliatrophin for mouse and human astrocytes

  title={Transforming growth factor alpha acts as a gliatrophin for mouse and human astrocytes},
  author={Ariane Sharif and Vincent Prevot and Francois Renault-Mihara and C{\'e}cile Allet and J. M. Studler and Brigitte Canton and H{\'e}rve Chneiweiss and M-P Junier},
Astrocyte death has been implicated in several neuropathological diseases, but the identification of molecules susceptible of promoting astrocyte survival has been elusive. We investigated whether transforming growth factor alpha (TGFα), an erbB1/EGFR ligand, which promotes glioma progression and affects astrocyte metabolism at embryonic and adult stages, regulates astrocyte survival. Primary serum-free astrocyte cultures from post-natal mouse and fetal human cortices were used. Transforming… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 15 references

Glia 46: 356–368

S Kleywegt
Duronio V, Scheid MP, Ettinger S. (1998). Cell Signal 10: • 2004

Cancer Cell 3: 519–523

P Peschard, M. Park
View 1 Excerpt

Oncogene 22: 6802–6809

C Bohm
Sibilia M, Steinbach JP, Stingl L, Aguzzi A, Wagner EF. • 2003

Cancer Res 62: 4307–4315

Loeffler JS.
Ciardiello F, Tortora G. (2003). Eur J Cancer 39: 1348–1354. Di Iorio P, Ballerini P, Traversa U, Nicoletti F, D’Alimonte I, • 2002

NeuroReport 13: 1921–1924

A Lienard
Schlessinger J. (2004). Science 306: 1506–1507. • 2002

Cell Immunol 208: 18–24

RA Prayson
Beck G, Fainzilber M. (2002). Neuron 33: 673–675. Bergmann A, Tugentman M, Shilo BZ, Steller H. (2002). Dev • 2001

J Comp Neurol 433: 86–100

Giffard RG, Swanson RA. (2005). Glia 50: 299–306. Hanson Jr MG, Shen S, Wiemelt AP, McMorris FA, Barres • 2001

J Neurosci 21: 1257–1264

S Higashiyama
Waterman H, Sabanai I, Geiger B, Yarden Y. (1998). J Biol • 2001

Nat Cell Biol 3: 150–157

WA Kuziel
Barna BP, Mattera R, Jacobs BS, Drazba J, Estes ME, • 2001

J Biol Chem 275: 6987–6995

WM Flanagan
Chakravarti A, Chakladar A, Delaney MA, Latham DE, • 2000

Similar Papers

Loading similar papers…