Transforming growth factor-alpha (TGF-alpha) and insulin gene expression in human fetal pancreas.

@article{Miettinen1992TransformingGF,
  title={Transforming growth factor-alpha (TGF-alpha) and insulin gene expression in human fetal pancreas.},
  author={P{\"a}ivi J Miettinen and Kristiina Heikinheimo},
  journal={Development},
  year={1992},
  volume={114 4},
  pages={833-40}
}
Transforming growth factor-alpha (TGF-alpha) mRNA is expressed in several pancreatic cancer cell lines, but its expression during normal fetal pancreas development has not been studied. We investigated the expression of TGF-alpha, its receptor (EGF-R) and insulin mRNA and their corresponding peptides in human fetal pancreata (15-20 gestation weeks). Polymerase chain reaction (PCR) and RNAase protection analysis revealed that TGF-alpha and insulin mRNAs were detectable in pancreas during the… CONTINUE READING

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