Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities.

@article{Lazar1988TransformingGF,
  title={Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities.},
  author={Eliane Lazar and Sugiko Watanabe and Stephen Dalton and Michael B. Sporn},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 3},
  pages={1247-52}
}
To study the relationship between the primary structure of transforming growth factor alpha (TGF-alpha) and some of its functional properties (competition with epidermal growth factor (EGF) for binding to the EGF receptor and induction of anchorage-independent growth), we introduced single amino acid mutations into the sequence for the fully processed, 50… CONTINUE READING