Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.

@article{Katsura2008TransformingGF,
  title={Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.},
  author={Hirokazu Katsura and Koichi Obata and Kan Miyoshi and Takashi Kondo and Hiroki Yamanaka and Kimiko Kobayashi and Yi Dai and T OSHIHIRO O DA Fukuoka and Masafumi Sakagami and Koichi Noguchi},
  journal={Glia},
  year={2008},
  volume={56 7},
  pages={723-33}
}
Mitogen-activated protein kinase (MAPK) plays an important role in the induction and maintenance of neuropathic pain. Transforming growth factor-activated kinase 1 (TAK1), a member of the MAPK kinase kinase family, is indispensable for the activation of c-Jun N-terminal kinase (JNK) and p38 MAPK. We now show that TAK1 induced in spinal cord astrocytes is crucial for mechanical hypersensitivity after peripheral nerve injury. Nerve injury induced a striking increase in the expression of TAK1 in… CONTINUE READING
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