Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo

@inproceedings{Peshavariya2014TransformingGF,
  title={Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo},
  author={Hitesh Mahendrabhai Peshavariya and Elsa C H Chan and Guei Sheung Liu and Fan Jiang and Gregory James Dusting},
  booktitle={Journal of cellular and molecular medicine},
  year={2014}
}
Angiogenesis, the formation of new blood vessels, is a key physiological event in organ development and tissue responses to hypoxia but is also involved in pathophysiologies such as tumour growth and retinopathies. Understanding the molecular mechanisms involved is important to design strategies for therapeutic intervention. One important regulator of angiogenesis is transforming growth factor-β1 (TGF-β1). In addition, reactive oxygen species (ROS) and the ROS-forming NADPH oxidase type 4 (Nox4… CONTINUE READING
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