Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.

@article{Wang2014TransformingGF,
  title={Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.},
  author={Bo Wang and Jay Chandra Jha and Shinji Hagiwara and Aaron McClelland and Karin Jandeleit-Dahm and Merlin C Thomas and Mark Cooper and Phillip Kantharidis},
  journal={Kidney international},
  year={2014},
  volume={85 2},
  pages={
          352-61
        }
}
Renal fibrosis results from excessive accumulation of extracellular matrix mainly driven by transforming growth factor-β1 (TGF-β1). Certain microRNAs have been implicated in this disease, and here we examine the role of let-7b. Rat proximal tubular epithelial cells (NRK52E) were treated with TGF-β1 for 3 days to assess the expression of markers of fibrosis and let-7b. These factors were also assessed in two mouse models representing early and more advanced diabetic nephropathy and in the non… CONTINUE READING
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