Transforming growth factor β signaling controls activities of human intestinal CD8(+)T suppressor cells.

@article{Rabinowitz2013TransformingGF,
  title={Transforming growth factor β signaling controls activities of human intestinal CD8(+)T suppressor cells.},
  author={Keren M Rabinowitz and Yuanyuan Wang and Edward Y. Chen and Zara Hovhannisyan and David C.-H. Chiang and M Cecilia Berin and Stephanie Dahan and Damien Chaussabel and Avi Ma'ayan and Lloyd Hitoshi Mayer},
  journal={Gastroenterology},
  year={2013},
  volume={144 3},
  pages={601-612.e1}
}
BACKGROUND & AIMS In healthy individuals, interactions between intestinal epithelial cells and lamina propria lymphocytes give rise to a population of CD8(+) T cells with suppressor functions (Ts cells). Disruption of Ts cell activities can lead to mucosal inflammation. We investigated what factors were required for expansion of the Ts cell population or loss of their activity in patients with Crohn's disease (CD). METHODS We developed a method to generate Ts cell lines from freshly isolated… CONTINUE READING