Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure.


We have previously shown that inhibition of transforming growth factor-β (TGF-β) signaling attenuates hypoxia-induced inhibition of alveolar development and abnormal pulmonary vascular remodeling in the newborn mice and that endothelin-A receptor (ETAR) antagonists prevent and reverse the vascular remodeling. The current study tested the hypothesis that… (More)
DOI: 10.1152/ajplung.00258.2011


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