Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.

@article{Shobe2016TransformingGF,
  title={Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.},
  author={Justin L. Shobe and Gary T. Philips and Thomas J. Carew},
  journal={Learning & memory},
  year={2016},
  volume={23 5},
  pages={182-8}
}
In this study, we explore the mechanistic relationship between growth factor signaling and kinase activity that supports the protein synthesis-dependent phase of long-term memory (LTM) consolidation for sensitization ofAplysia Specifically, we examine LTM for tail shock-induced sensitization of the tail-elicited siphon withdrawal (T-SW) reflex, a form of memory that requires both (i) extracellular signal-regulated kinase (ERK1/2; MAPK) activity within identified sensory neurons (SNs) that… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 37 references

The regulation of transcription in memory consolidation.

Cold Spring Harbor perspectives in biology • 2014
View 3 Excerpts

MAPK establishes a molecular context that defines effective training patterns for long-term memory formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 1 Excerpt

PKC differentially translocates during spaced and massed training in Aplysia.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 1 Excerpt

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