Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells.

@article{Shin2011TransformingGF,
  title={Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells.},
  author={Jeong-Ah Shin and Oak-Kee Hong and Hye-Jung Lee and Sung-Yoon Jeon and Ji-Won Kim and Seung-Hwan Lee and Jae-Hyoung Cho and Jung-min Lee and Yoon-Hee Choi and Sang-Ah Chang and Ho-Young Son and Joo-Han Kim and Kun-Ho Yoon},
  journal={Journal of cellular biochemistry},
  year={2011},
  volume={112 1},
  pages={179-88}
}
Pancreatic duct cells are considered a potential source of β-cell regeneration, and transforming growth factor-β (TGF-β) has been suggested to perform an important role in these processes, but the underlying mechanism of the signal pathways, especially in humans, remains poorly understood. To evaluate the role of TGF-β1, pancreatic duct cells were isolated from three brain-dead organ donors. Pancreatic cell clusters harvested after islet isolation were dispersed to single cells and cultured in… CONTINUE READING
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